PCMC organizes an annual workshop that brings together leaders in the field to explore innovative directions in cancer model development and preclinical therapeutic strategies. The workshop covers both in vivo mouse models and emerging non-animal models (NAMs), such as organoids and organs on chips. Participants identify challenges in current methodologies and regulatory frameworks, share best practices, foster collaborative efforts, and chart future directions for the field. The workshop also provides ample networking opportunities with academic and technology partners.